강건욱 - 서울대학교 첨단융합학부

혁신신약전공

강건욱 교수

Keon Wook Kang

위치약학대학 20동 326호

연락처02-880-7851

이메일kwkang@snu.ac.kr

학위박사 / 약학, 서울대학교

분야항암제저항성 종양 치료 작용점 규명 및 후보 약물 발굴

학력

– 학사: 서울대학교 약학대학 약학과 (1993)
– 석사: 서울대학교 대학원 약학과(약물학전공) (1995)
– 박사: 서울대학교 대학원 약학과(약물학전공) (1999)

주요 경력

– 1999~2002: 서울대학교 신의약품개발연구센터 박사연구원
– 2002~2003: University of California, Irvine 박사후연구원
– 2003~2011: 조선대학교 약학대학 전임강사, 조교수, 부교수
– 2011~현재: 서울대학교 약학대학 교수

최근 연구 성과

– Phuong NTT, Kim SK, Lim SC, Kim HS, Kim TH, Lee KY, Ahn SG, Yoon JH, Kang KW. Role of PTEN Promoter Methylation in Tamoxifen-Resistant Breast Cancer Cells. *Breast Cancer Research and Treatment*. 2011, in press.
– Oh WK, Cho KB, Hien TT, Kim TH, Kim HS, Dao TT, Han HK, Kwon SM, Ahn SG, Yoon JH, Kim TH, Kim YG, Kang KW. Amurensin G, a Potent Natural SIRT1 Inhibitor, Rescues Doxorubicin Responsiveness via Down-Regulation of Multidrug Resistance 1. *Molecular Pharmacology*. 2010;78(5):855–864.
– Kim SE, Lee MY, Lim SC, Hien TT, Kim JW, Ahn SG, Yoon JH, Kim SK, Choi HS, Kang KW. Role of Pin1 in Neointima Formation: Down-Regulation of Nrf2-Dependent Heme Oxygenase-1 Expression by Pin1. *Free Radical Biology & Medicine*. 2010;48(12):1644–1653.
– Hien TT, Kim ND, Pokharel YR, Oh SJ, Lee MY, Kang KW. Ginsenoside Rg3 Increases Nitric Oxide Production via Phosphorylation and Expression of Endothelial Nitric Oxide Synthase: Essential Roles of Estrogen Receptor-Dependent PI3-Kinase and AMP-Activated Protein Kinase. *Toxicology and Applied Pharmacology*. 2010;246(3):171–183.
– Kim JW, Lim SC, Lee MY, Lee JW, Oh WK, Kim SK, Kang KW. Inhibition of Neointimal Formation by trans-Resveratrol: Role of PI3-Kinase-Dependent Nrf2 Activation in Heme Oxygenase-1 Induction. *Molecular Nutrition & Food Research*. 2010;54(10):1497–1505.
– Kang KW, Chun MK, Kim O, Subedi RK, Ahn SG, Yoon JH, Choi HK. Doxorubicin-Loaded Solid Lipid Nanoparticles to Overcome Multidrug Resistance in Cancer Therapy. *Nanomedicine*. 2010;6(2):210–213.
– Cho KB, Cho MK, Lee WY, Kang KW. Overexpression of c-Myc Induces Epithelial–Mesenchymal Transition in Mammary Epithelial Cells. *Cancer Letters*. 2010;293(2):230–239.
– Pokharel YR, Kim ND, Han HK, Oh WK, Kang KW. Increased Ubiquitination of Multidrug Resistance 1 by Ginsenoside Rd. *Nutrition and Cancer*. 2010;62(2):252–259.
– Jeong HG, Pokharel YR, Lim SC, Hwang YP, Han EH, Yoon JH, Ahn SG, Lee KY, Kang KW. Novel Role of Pin1 Induction in Type II Collagen-Mediated Rheumatoid Arthritis. *Journal of Immunology*. 2009;183(10):6689–6697.
– Kim MR, Choi HS, Yang JW, Park BC, Kim JA, Kang KW. Enhancement of VEGF-Mediated Angiogenesis in Tamoxifen-Resistant Breast Cancer Cells: Role of Pin1 Overexpression. *Molecular Cancer Therapeutics*. 2009;8(8):2163–2171.

Education

– B.S.: Seoul National University (1993): Pharmacy
– M.S.: Seoul National University (1995): Pharmacy (Major in Pharmacology)
– Ph.D.: Seoul National University (1999): Pharmacy (Major in Pharmacology)

Professional Experience

– Seoul National University, Center for New Drug Development: Postdoctoral Researcher (1999–2002)
– University of California, Irvine: Postgraduate Researcher (2002–2003)
– College of Pharmacy, Chosun University: Full-time Lecturer, Assistant Professor, Associate Professor (2003–2011)
– College of Pharmacy, Seoul National University: Professor (2011–present)

Recent Research Achievements

첨단융합 최고위과정

강건욱 교수

Keon Wook Kang