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첨단융합 최고위과정

혁신신약전공

서형석 조교수

Hyungseok Seo

위치약학대학 20동 305호
연락처02-880-2458
이메일h.seo@snu.ac.kr
학위박사 / 분자의학 및 바이오제약학, 서울대학교
분야면역학 및 세포유전자치료
학력
– 학사: 서울대학교 동물생명공학 (2012)
– 박사: 서울대학교 분자의학및바이오제약학 (2017)
주요 경력
– 2017~2018: 서울대학교 종합약학연구소 연수연구원
– 2018~2021: La Jolla Institute for Immunology 박사후연구원
– 2021~2022: Novartis Institutes for Biomedical Research Principal Scientist
– 2022~현재: 서울대학교 약학대학 약학과 조교수
주요 수상 및 영예
– 2018–2019: AACR-Genentech Cancer Immunology Research Fellowship
– 2019–2022: Cancer Research Institute Irvington Fellowship
– 2023–2026: Korea Drug Development Fund
– 2023–2028: Samsung Science & Technology Foundation
– 2024: 보건의료기술진흥 유공자 보건복지부 장관 표창(신진연구)
최근 연구 성과
– Anticoagulation Therapy Promotes the Tumor Immune Microenvironment and Potentiates the Efficacy of Immunotherapy by Alleviating Hypoxia, *J Immunother Cancer*, 2021
– BATF and IRF4 Cooperate to Counter Exhaustion in Tumour-Infiltrating CAR T Cells, *Nature Immunology*, 2021
– Enhanced Immunogenicity of Engineered HER2 Antigens Potentiates Antitumor Immune Responses, *Vaccines*, 2020
– GITR Agonism Triggers Antitumor Immune Responses through IL21-Expressing Follicular Helper T Cells, *Cancer Immunology Research*, 2020
– Differentiation of c-Kit+CD24+ Natural Killer Cells into Myeloid Cells in a GATA-2-Dependent Manner, *FASEB Journal*, 2020
– Monocyte-Derived Dendritic Cells Dictate the Memory Differentiation of CD8+ T Cells During Acute Infection, *Frontiers in Immunology*, 2019
– Paradoxical Association of TET Loss of Function with Genome-Wide DNA Hypomethylation, *Proceedings of the National Academy of Sciences USA*, 2019
– TOX and TOX2 Transcription Factors Cooperate with NR4A Transcription Factors to Impose CD8+ T Cell Exhaustion, *Proceedings of the National Academy of Sciences USA*, 2019
– GM-CSF Promotes Antitumor Immunity by Inducing Th9 Cell Responses, *Cancer Immunology Research*, 2019
– NR4A Transcription Factors Limit CAR T Cell Function in Solid Tumours, *Nature*, 2019
– Activation of NKT Cells in an Anti-PD-1-Resistant Tumor Model Enhances Anti-Tumor Immunity by Reinvigorating Exhausted CD8 T Cells, *Cancer Research*, 2018
– IL-21-Mediated Reversal of NK Cell Exhaustion Facilitates Anti-Tumour Immunity in MHC Class I-Deficient Tumours, *Nature Communications*, 2017
– Tumor-Derived Osteopontin Suppresses Antitumor Immunity by Promoting Extramedullary Myelopoiesis, *Cancer Research*, 2014
– Serum Amyloid A3 Exacerbates Cancer by Enhancing the Suppressive Capacity of Myeloid-Derived Suppressor Cells via TLR2-Dependent STAT3 Activation, *European Journal of Immunology*, 2014
– Enhanced Antitumor Immunotherapeutic Effect of B-Cell-Based Vaccine Transduced with Modified Adenoviral Vector Containing Type 35 Fiber Structures, *Gene Therapy*, 2014
Education
– B.S.: Seoul National University (2012): Animal Biotechnology
– Ph.D.: Seoul National University (2017): Molecular Medicine and Biopharmaceutical Sciences
Professional Experience
– 2017–2018: Research Fellow, Research Institute of Pharmaceutical Sciences, Seoul National University
– 2018–2021: Postdoctoral Fellow, La Jolla Institute for Immunology
– 2021–2022: Principal Scientist, Novartis Institutes for Biomedical Research
– 2022–Present: Assistant Professor, College of Pharmacy, Seoul National University
Honors and Awards (Selected)
– 2018–2019: AACR–Genentech Cancer Immunology Research Fellowship
– 2019–2022: Cancer Research Institute Irvington Fellowship
– 2023–2026: Korea Drug Development Fund
– 2023–2028: Samsung Science & Technology Foundation
– 2024: Minister of Health and Welfare Commendation for Contribution to Health Technology Advancement (Early-Career Researcher)
Recent Research Achievements
– Anticoagulation Therapy Promotes the Tumor Immune Microenvironment and Potentiates the Efficacy of Immunotherapy by Alleviating Hypoxia, *J Immunother Cancer*, 2021
– BATF and IRF4 Cooperate to Counter Exhaustion in Tumour-Infiltrating CAR T Cells, *Nature Immunology*, 2021
– Enhanced Immunogenicity of Engineered HER2 Antigens Potentiates Antitumor Immune Responses, *Vaccines*, 2020
– GITR Agonism Triggers Antitumor Immune Responses through IL21-Expressing Follicular Helper T Cells, *Cancer Immunology Research*, 2020
– Differentiation of c-Kit+CD24+ Natural Killer Cells into Myeloid Cells in a GATA-2-Dependent Manner, *FASEB Journal*, 2020
– Monocyte-Derived Dendritic Cells Dictate the Memory Differentiation of CD8+ T Cells During Acute Infection, *Frontiers in Immunology*, 2019
– Paradoxical Association of TET Loss of Function with Genome-Wide DNA Hypomethylation, *Proceedings of the National Academy of Sciences USA*, 2019
– TOX and TOX2 Transcription Factors Cooperate with NR4A Transcription Factors to Impose CD8+ T Cell Exhaustion, *Proceedings of the National Academy of Sciences USA*, 2019
– GM-CSF Promotes Antitumor Immunity by Inducing Th9 Cell Responses, *Cancer Immunology Research*, 2019
– NR4A Transcription Factors Limit CAR T Cell Function in Solid Tumours, *Nature*, 2019
– Activation of NKT Cells in an Anti-PD-1-Resistant Tumor Model Enhances Anti-Tumor Immunity by Reinvigorating Exhausted CD8 T Cells, *Cancer Research*, 2018
– IL-21-Mediated Reversal of NK Cell Exhaustion Facilitates Anti-Tumour Immunity in MHC Class I-Deficient Tumours, *Nature Communications*, 2017
– Tumor-Derived Osteopontin Suppresses Antitumor Immunity by Promoting Extramedullary Myelopoiesis, *Cancer Research*, 2014
– Serum Amyloid A3 Exacerbates Cancer by Enhancing the Suppressive Capacity of Myeloid-Derived Suppressor Cells via TLR2-Dependent STAT3 Activation, *European Journal of Immunology*, 2014
– Enhanced Antitumor Immunotherapeutic Effect of B-Cell-Based Vaccine Transduced with Modified Adenoviral Vector Containing Type 35 Fiber Structures, *Gene Therapy*, 2014